Sylvester Researchers Partner with County to Provide Important COVID-19 Answers

Testing will help reveal the true extent of the coronavirus infection
Miami Dade

The director and deputy director of Sylvester’s Firefighter Cancer Initiative, Dr. Erin Kobetz and Dr. Alberto Caban-Martinez, are leading the COVID-19 testing collaboration with Miami-Dade County.

When Miami Dade-County leaders set out to quantify the extent of COVID-19 infection in the county, they tapped researchers from Sylvester Comprehensive Cancer Center at the Miller School of Medicine to lead the effort.

Erin Kobetz, Ph.D., M.P.H., and Alberto Caban-Martinez, D.O., Ph.D., M.P.H., are the director and deputy director, respectively, of Sylvester’s Firefighter Cancer Initiative. They’re applying their expertise at assessing the burden of cancer among first responders to providing a better picture of how many people in Miami-Dade have been infected with the novel coronavirus.

Miami Dade

Katerina Santiago, UHealth research support specialist, and a Miami-Dade County firefighter prepare to administer tests at a county testing site.

Official Numbers May Be Low

Miami-Dade has more confirmed cases than any other county in Florida, but experts have believed for some time that the burden of infection is higher than what has been reported.

“We are likely significantly underestimating disease prevalence, with potentially eight to 10 people actually infected for every one positive test reported in daily statistics,” Dr. Kobetz said. “With limited testing availability, we are largely moving in the dark in terms of understanding what is happening locally, including the proportion of asymptomatic individuals who are positive, and how the curve of infection may change as social distancing and stronger shelter-in-place initiatives are widely practiced.”

Dr. Kobetz points out that this “community surveillance” program — called SPARK-C, which stands for Surveillance Program Assessing Risk and Knowledge of Coronavirus — is the first of its kind nationally and incredibly important for a successful public health response.

The nasal swab test currently used for screening detects the actual virus and is considered the gold standard when making clinical decisions. This new public health surveillance effort will employ a different kind of test using a drop of blood from a fingertip to check for antibodies to the virus, which signal past or present infection. The company that makes this serologic test has an Emergency Use Application under review by the Food and Drug Administration.

Testing Random Cross Sections

Miami-Dade County Mayor Carlos A. Gimenez purchased 10,000 kits to test random cross sections of the population. Florida Power & Light is helping with the process of randomly selecting addresses. Those residents will receive a recorded call from Mayor Gimenez asking if they would like to participate. Those who are interested in volunteering will be routed to a phone line designated for SPARK-C.

“The phone line will be staffed by public health and medical students from the University of Miami who speak English, Spanish, and Creole. These students will conduct an initial screening and then will schedule the volunteers who consent to one of 10 testing sites designated solely for this community initiative,” Dr. Caban-Martinez explained.

Members of Emergency Medical Services Ocean Rescue will be administering the finger-prick test. Results will be provided to participants the next day.

The Sylvester research team will be collecting and analyzing the data.

Diversity Will Offer Lessons

“I think we will learn a lot about how COVID-19 is affecting our local community, whether certain geographies and/or population sub-groups have a greater infectivity rate, and most importantly, what to do about it now and in the future,” Dr. Kobetz said. “And I think doing this work in South Florida, given our significant diversity, will offer critical lessons learned for the broader U.S. and Western Hemisphere. Our data can drive local and global solutions.”

Some of the test kits will also be used to assess infection among first responders in Miami-Dade County and people experiencing homelessness.

“The rapid spread of COVID-19 throughout the world and our country has forced us to figure out new ways to collaborate,” Mayor Gimenez said. “In our community, we are proud to often engage in public-private partnerships, and this testing program is an outstanding example of this. With our combined efforts, we look forward to applying what we can learn from this study and, hopefully, help bring an end to this public health crisis.”

UNIVERSITY OF MIAMI MEDICINE
SPRING 2020